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心血管疾病尤其是冠状动脉硬化性心脏病具有很高的死亡率和发病率,对这些冠脉疾病的病因分析,认为动脉粥样硬化是主要原因。动脉壁脂质沉积和血管平滑肌细胞的异常迁移与增殖是动脉粥样硬化形成的两个关键步骤。目前抗动脉粥样硬化以调脂药物如三羟基三甲基戊二酰辅酶A(HMG-COA)还原酶抑制剂(即他汀类药物)为主,临床实验和基础研究表明:他汀类药物不仅具有调控血浆胆固醇的主要作用,而且还涉及其非调脂的抗动脉粥样硬化作用,如抗炎症反应、抑制血小板聚集、抑制血管平滑肌细胞增殖与迁移、促进血管平滑肌细胞凋亡和改善内皮功能等。本文主要就他汀类药物对血管平滑肌细胞增殖、迁移、凋亡的影响及其机制做如下综述。
Cardiovascular diseases, especially coronary heart disease, have a high mortality and morbidity. The etiology of these coronary diseases is attributed to atherosclerosis. Arterial wall lipid deposition and abnormal migration and proliferation of vascular smooth muscle cells are two key steps in the development of atherosclerosis. At present anti-atherosclerosis lipid-lowering drugs such as trihydroxy trimethyl glutaryl coenzyme A (HMG-COA) reductase inhibitors (ie, statin drugs), clinical trials and basic research shows that: statins not only It plays a major role in the regulation of plasma cholesterol. It is also involved in its non-lipid-lowering anti-atherosclerotic effects such as anti-inflammation, inhibition of platelet aggregation, inhibition of vascular smooth muscle cell proliferation and migration, promotion of vascular smooth muscle cell apoptosis and improvement of endothelial function Wait. In this paper, the main effects of statins on proliferation, migration and apoptosis of vascular smooth muscle cells and their mechanisms are summarized as follows.