论文部分内容阅读
为观察他汀类药物对血清甘油三酯的作用以及治疗前基础血清甘油三酯水平对其治疗作用的影响，本文分析了１９９４ 年～１９９８ 年期间进行的辛伐他汀和洛伐他汀两项多中心临床药物试验。治疗前血清总胆固醇≥５ ．９８ ｍｍｏｌ／ Ｌ，甘油三酯≤４ ．５２ ｍｍｏｌ／ Ｌ，按治疗前基础血清甘油三酯水平分组：辛伐他汀试验者１６６ 例，口服辛伐他汀１０ ｍｇ／ｄ ；洛伐他汀试验者１４６例，口服洛伐他汀２０ ｍｇ／ｄ ，疗程均为８ 周。结果发现，治疗前基础血清甘油三酯水平愈高，他汀类药物降低血清甘油三酯的作用愈明显，辛伐他汀和洛伐他汀降低血清甘油三酯的幅度均与治疗前基础血清甘油三酯水平呈正相关（ ｒ＝ ０ ．３１５５ 和ｒ＝ ０ ．３３４１ ， Ｐ 均＜ ０ ．０１） 。结果提示，他汀类药物能有效地降低高甘油三酯血症患者的血清甘油三酯水平，其降低幅度与治疗前的基础血清甘油三酯水平有关。
To investigate the effects of statins on serum triglycerides and the effect of pretreatment serum triglyceride levels on their therapeutic effects, two multicentre simvastatin and lovastatin trials conducted between 1994 and 1998 Clinical drug test. Before treatment serum total cholesterol ≥ 5. 98 mmol / L, triglycerides ≤ 4. 52 mmol / L, according to the baseline serum triglyceride level before treatment: 166 cases of simvastatin test, oral simvastatin 10 mg / d; lovastatin test of 146 cases, oral lovastatin 20 mg / d, The course of treatment is 8 weeks. The results showed that before treatment, the higher the basal level of serum triglyceride, statin drugs to reduce the role of serum triglyceride more obvious, simvastatin and lovastatin reduce the rate of serum triglyceride were basal serum triglyceride before treatment The levels were positively correlated (r = 0.31 5 and r = 0.3341, P <0.01). The results suggest that statins can effectively reduce the level of serum triglyceride in patients with hypertriglyceridemia, the extent of reduction and baseline serum triglyceride levels before treatment.