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本文报道中药复方制剂胃萎灵(主要由山楂、陈皮、芍药、甘草等组成)ig对大鼠的长期毒性,绝大部分观察指标(一般行为活动、血象、血液生化指标和病检器官等)在给药组和对照组间未见明显差别,仅大剂量组在给药期间体重和食量低于其它组且网织红细胞高于其它组,停药后恢复正常。实验表明大鼠ig胃萎灵相当于推存临床用量100倍连续3个月未显示严重的药物性毒性反应。
This article reports on the long-term toxicity of ig, a traditional Chinese medicine compound preparation (mainly consisting of hawthorn, tangerine peel, peony, licorice, etc.) ig, for most of the observations (general behavioral activities, blood, blood biochemical indicators, organs for disease detection, etc.) There was no significant difference between the administration group and the control group. Only the high-dose group had lower body weight and food intake during the administration period than the other groups, and the reticulocytes were higher than the other groups and returned to normal after drug withdrawal. Experiments showed that the rat ig Wei Weiling was equivalent to pushing the clinical dose 100 times for 3 consecutive months without showing severe drug toxicity.