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1983年7月至1984年10月,对滇南5个间日疟原虫分离株作了实验感染。蚊传结果表明,在当地属于热带或亚热带地区所见的间日疟,其潜伏期有长有短,在39例志愿受试者中出现2例长潜伏期(268和284天),37例短潜伏期(12.2±1.9天)。单用氯喹1.5g基质三天疗法治疗的21例复发率为95.2％,15例伍用伯喹210mg基质十四天疗法后未见复发。所见的三种复发类型中,以远期复发居多(75％),无近远期复发之分的频繁复发次之(15％),近期复发最少(10％)。复发的一般规律是:第一潜隐期短者第二潜隐期长,第一潜隐期长者则第二潜隐期短。 滇南间日疟以其潜伏期长短相兼,复发以远期为主、对根治药伯喹极为敏感等一系列表现,有别于以溪桑株为代表的热带型,而与温带型的特性基本相符。可见各地区间日疟原虫的生物学特性及其表现相当复杂,查明我国代表性地区间日疟的客观生态规律,为制订切实有效的防治方法提供科学依据很有必要。
From July 1983 to October 1984, five P. vivax isolates from southern Yunnan were experimentally infected. The results of mosquito transmission showed that the incubation period of P. vivax which was found in the tropical or subtropical areas of the country was short and long, with two cases of long latency (268 and 284 days) in 39 volunteers and 37 cases of short latency (12.2 ± 1.9 days). The recurrence rate of 21 cases treated with chloroquine 1.5g matrix three days therapy was 95.2%, and no recurrence was seen in 15 cases with primary quinone 210mg matrix after 14 days therapy. Of the three recurrence types seen, the most frequent recurrence (75%), the second (15%) with no recurrence, and the least recent recurrence (10%). The general rule of recurrence is: the first latent period of the second latent period is short, the first latent period of the second latent period is short. In southern Yunnan, P. vivax is characterized by a combination of its length of latency, long-term relapse, long-term relapse, and sensitivity to Radix Puerariae, which is different from the tropical type represented by Xisang Strain. Basic match. It can be seen that the biological characteristics and performance of Plasmodium vivax in various regions are quite complex. It is necessary to find out the objective ecological rules of Vivax malaria in representative regions of China and provide a scientific basis for formulating effective and effective prevention and treatment methods.