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AIM; To investigate the protective effect of HD-03 in experimental cirrhosis following chronic intoxication with thioacetamide (TAA). METHODS; The effect of HD-03 (750 mg/kg po) was studied in rats following TAA-induced intoxication (50 mg/kg po) for a period of 90 d. HD-03 was administered as an aqueous suspen-sion . Levels of biochemical markers indicative of hepa-totoxicity were assessed in serum and liver. Histopatho-logical evaluation of liver was also carried out to find out the protective effect of HD-03 following TAA-induced chronic intoxication. RESULTS; Administration of TAA at a dose of 50 mg/kg po for 90 d resulted in a sig-nificant derangement of serum [ serum glutamic pyruvate transaminase ( SGPT), serum glutamic oxaloacetate transaminase (SGOT) , alkaline phosphatase (ALP), al-bumin and bilirubin] and hepatic (triglycerides, protein, hydroxyproline, collagen and glycogen) biochemical pa-rameters. Histopathological evaluation of liver sections following TAA-intoxication showed necrosis and
To investigate the protective effect of HD-03 in an experimental cirrhosis following chronic intoxication with thioacetamide (TAA). METHODS; The effect of HD-03 (750 mg / kg po) was studied in rats following TAA-induced intoxication Levels of biochemical markers were indicative of hepa-totoxicity were were in serum and liver. Histopatho-logical evaluation of liver was also carried out to RESULTS of TAA-induced chronic intoxication. RESULTS; Administration of TAA at a dose of 50 mg / kg po for 90 d resulted in a sig-nificant derangement of serum [serum glutamic pyruvate transaminase (SGPT) , serum glutamic oxaloacetate transaminase (SGOT), alkaline phosphatase (ALP), al-bumin and bilirubin] and hepatic (triglycerides, protein, hydroxyproline, collagen and glycogen) biochemical pa- rameters. Histopathological evaluation of liver sections following TAA-intoxication s howed necrosis and