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Objective:The aim of this study was to investigate the expression of BRAF of prostate cancer,and to explore its relations with clinic-pathological factors.Methods:Immunohistochemistry was used to detect the expression of BRAF in 74 cases of prostate cancer,and 51 cases of benign prostate hyperplasia (BPH).Results:The positive rate of BRAF had significant difference between patients with prostate cancer and BPH (P < 0.05).The expression of BRAF was correlated with grade and stage of prostate cancer (P 0.05).Conclusion:The expression of BRAF may play a role in the tumorigenesis and progression of colorectal cancer.BRAF could be a factor to diagnose the typing of prostate cancers and predict the prognosis of prostate cancers.