论文部分内容阅读
目的 探讨 2型糖尿病肾病患者血清脂蛋白 (a) [Lp(a) ]质量浓度与纤溶功能的关系。方法 132例 2型糖尿病肾病患者分为A组 [尿白蛋白排泄率 (UAER) >2 0 0 μg/min ,n =4 2 ]、B组 (UAER介于 2 0 μg/min～ 2 0 0 μg/min ,n =4 0 )、C组 (UAER <2 0 μg/min ,n =5 0 ) ,健康对照组 (D组 ) 80例 ,均测定血脂 [包括血清Lp(a) ]、组织型纤溶酶原激活物 (tPA)及纤溶酶原激活物抑制剂 (PAI)活性、糖化血红蛋白A1c(GHbA1c)、内生肌酐清除率 (Ccr)和肱动脉血压。结果 A和B组血清Lp(a)较C组和D组明显升高 (P <0 0 1) ,且Lp(a)与PAI活性正相关 (r =0 6 8,P <0 0 5 ) ,与tPA活性负相关 (r =- 0 72 ,P <0 0 1)。结论 Lp(a)和 2型糖尿病肾病时纤溶功能障碍密切相关 ,是促使糖尿病肾病病变进展的重要因素。
Objective To investigate the relationship between serum concentration of lipoprotein (a) [Lp (a)] and fibrinolytic function in patients with type 2 diabetic nephropathy. Methods A total of 132 patients with type 2 diabetic nephropathy were divided into group A (UAER> 200 μg / min, n = 4 2), group B (UAER ranged from 20 μg / min to 200 (P <0.05). The levels of serum lipids (including serum Lp (a)], tissue in group C (UAER <20 μg / min, n = 50) and healthy control group (group D) Type plasminogen activator (tPA) and plasminogen activator inhibitor (PAI) activity, glycosylated hemoglobin A1c (GHbA1c), endogenous creatinine clearance (Ccr) and brachial artery blood pressure. Results Serum Lp (a) in groups A and B were significantly higher than those in groups C and D (P <0.01), and Lp (a) was positively correlated with PAI activity (r = 0 68, P 0 05) , Negatively correlated with tPA activity (r = - 0 72, P <0.01). Conclusions Lp (a) is closely related to fibrinolytic dysfunction in type 2 diabetic nephropathy and is an important factor to promote the progression of diabetic nephropathy.