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目的探讨左旋咪唑联合维生素B_(12)治疗复发性口腔溃疡的效果。方法将2014年8月—2015年8月收治的复发性口腔溃疡患者76例随机分为观察组和对照组各38例,对照组行单纯左旋咪唑治疗,观察组行左旋咪唑与维生素B_(12)联合治疗,对两组血清中白介素-6、维生素B_(12)水平与溃疡愈合时间、复发率及不良反应情况,计量资料组间比较采用t检验,计数资料采用χ~2检验,以P<0.05为差异有统计学意义。结果治疗后观察组血清白介素-6水平(56.48±10.20)pg·ml-1、维生素B_(12)水平(523.36±15.60)μg·ml-1均优于对照组(t=60.215、56.0795,均P<0.05);观察组溃疡愈合时间比对照组短(t=6.743,P<0.05),预后1年复发概率比对照组低(χ~2=3.563,P<0.05)。结论复发性口腔溃疡者行左旋咪唑与维生素B_(12)联合医治能够改善血清白介素-6和维生素B_(12)水平,缩短溃疡愈合时间,降低疾病复发概率,且不良反应少,临床推广价值较高。
Objective To investigate the effect of levamisole combined with vitamin B_ (12) in the treatment of recurrent oral ulcer. Methods A total of 76 patients with recurrent oral ulcer admitted from August 2014 to August 2015 were randomly divided into observation group (38 cases) and control group (38 cases). The control group was treated with levamisole alone. The observation group was treated with levamisole and vitamin B 12 ) Combined treatment of serum interleukin -6, vitamin B 12 levels and ulcer healing time, recurrence rate and adverse reactions, measurement data were compared using t test, the count data using the χ ~ 2 test to P <0.05 for the difference was statistically significant. Results After treatment, the levels of interleukin-6 (56.48 ± 10.20) pg · ml-1 and vitamin B 12 (523.36 ± 15.60) μg · ml-1 in the observation group were significantly higher than those in the control group (t = 60.215 and 56.0795, P <0.05). The ulcer healing time in the observation group was shorter than that in the control group (t = 6.743, P <0.05), and the one-year recurrence probability in the observation group was lower than that in the control group (χ ~ 2 = 3.563, P <0.05). Conclusions Levamisole and vitamin B_ (12) combined treatment can improve serum interleukin-6 and vitamin B_ (12) levels, shorten the healing time of ulcer and reduce the probability of disease recurrence, with less adverse reactions high.