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目的：探讨妊娠高血压综合征（妊高征）患者脐血、羊水中降钙素基因相关肽（ Ｃ Ｇ Ｒ Ｐ）含量的变化。方法：应用放射免疫测定法，观察２６ 例正常妊娠妇女和 ３２ 例妊高征患者脐血与羊水中 Ｃ Ｇ Ｒ Ｐ含量的变化。结果：脐动脉血中 Ｃ Ｇ Ｒ Ｐ含量，妊高征患者显著高于正常妊娠者（ Ｐ＜ ０．０５），且随着病情的加重逐渐增加，重度者显著高于轻度者（ Ｐ＜ ０．０５）；羊水中 Ｃ Ｇ Ｒ Ｐ含量妊高征患者显著高于正常妊娠对照组（ Ｐ＜ ０．０５）；脐动脉血、羊水中 Ｃ Ｇ Ｒ Ｐ含量的变化与新生儿 １ ｍ ｉｎ Ａｐｇａｒ 评分呈显著负相关（ Ｐ＜ ００１， Ｐ＜ ０．０５）。结论：脐动脉血、羊水中 Ｃ Ｇ Ｒ Ｐ含量的变化可能与胎儿宫内缺氧有关。
Objective: To investigate the changes of calcitonin gene-related peptide (C G R P) in cord blood and amniotic fluid of patients with pregnancy induced hypertension (PIH). Methods: Radioimmunoassay was used to observe the changes of C G R P in umbilical cord blood and amniotic fluid in 26 normal pregnant women and 32 patients with PIH. Results: The levels of CGRP and PIH in umbilical arterial blood were significantly higher than those in normal pregnancy (P <0.05), and gradually increased with the severity of the disease, and those with severe PIH were significantly higher than those with mild PIH (P < 0.05). The level of C G R P in amniotic fluid in pregnancy induced hypertension was significantly higher than that in normal pregnancy control group (P <0.05). The change of C G R P in umbilical artery and amniotic fluid was similar to that of neonatal 1 m in Apgar score was significantly negatively correlated (P <0 01, P <0.05). Conclusion: The changes of C G R P content in umbilical artery and amniotic fluid may be related to intrauterine hypoxia.