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从五风藤的地上部分95%乙醇提取物中首次分离得到12个化合物,应用波谱方法及与已知品对照的手段鉴定它们为:lup-20(29)-en-3-one(1),羽扇豆醇(2),β-谷甾醇(3),齐墩果酸(4),乌苏酸(5),β-胡萝卜苷(6),五加苷K(7),hederagenin3-O-α-L-rhamnopyranosyl-(1→2)-α-L-arabinopyranoside(8),β-萘乙酸(9),3-O-α-L-rhamnopyranosyl-(1→2)-[β-D-glucopyranosyl-(1→3)]-α-L-arabinopyranosy1 oleanolic acid 28-O-α-L-rhamnopyranosyl-(1→4)-β-D-glucopyranosyl-(1→6)-β-D-glucopyranosyl ester(10),3-O-α-L-rhamnopyranosyl-(1→2)-O-β-D-glucopyranosyl-(1→2)-α-L-arabinopyranosyl oleanolic acid(11),3-O-(β-D-glucopyranosiduronic acid)-oleanolic acid 28-O-β-D-glucopyranosyl ester(12).体外细胞毒活性筛选结果表明化合物7和8具有较强的细胞毒活性.
Twelve compounds were isolated from the 95% ethanol extract of the aerial parts of V. amurense for the first time. They were identified as lup-20 (29) -en-3-one (1) by spectroscopic methods and by comparison with known products (2), β-sitosterol (3), oleanolic acid (4), ursolic acid (5), β-daucosterol (6), penta glycoside K (7), hederagenin 3-O L-rhamnopyranosyl- (1 → 2) -α-L-arabinopyranoside (8), β-naphthylacetic acid (9) -glucopyranosyl- (1 → 3)] - α-L-arabinopyranosy1 oleanolic acid 28-O-α-L-rhamnopyranosyl- (1 → 4) -β-D-glucopyranosyl- (1 → 2) -O-β-D-glucopyranosyl- (1 → 2) -α-L-arabinopyranosyl oleanolic acid (11), 3-O- (β-D-glucopyranosiduronic acid) -oleolic acid 28-O-β-D-glucopyranosyl ester (12) in vitro cytotoxic activity of screening compounds 7 and 8 showed strong cytotoxic activity.