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本文报告从广西黄花夹竹桃(Thevetia peruviana Schum.)核仁获得的neriifolin(N)的药理,测定了生物活性(猫和豚鼠),用猫进行了肝消除、十二指肠给药后效应、消除、蓄积、毒性实验;还用g-strophanthin(G)及k-strophanthin(K)进行猫活性致死量与肝消除的比较实验,证明N的生物活性比文献报告者强;N对猫与豚鼠活性致死量之比为1:3.29;G、N、K对猫活性致死量之比,依序为1:1.42:2.35.N的肠吸收较慢,肝消除达27％,故经消化道给药似不甚适宜;而G、K的肝消除均为0.N的作用可复性较大,与文献报告G、羊角拗甙、lanatosid C相似,N蓄积较低和毒性较小,均与文献报告者相似;治疗指数为6.0,与文献报告羊角拗甙相似;表明N用药较安全。
This article reports the pharmacology of neriifolin (N) obtained from the nucleolus of Thevetia peruviana Schum., The bioactivity (cats and guinea pigs), liver elimination with cats, post-duodenal administration , Eliminating, accumulating and toxicity experiments. The comparative experiments of lethal amount and hepatic elimination of cat with g-strophanthin (G) and k-strophanthin (K) also showed that the biological activity of N was stronger than that reported in the literature; The lethal dose ratio of guinea pigs was 1: 3.29; the ratio of lethal dose of G, N, K to cat activity was 1: 1.42: 2.35, the intestinal absorption was slower and the hepatic elimination reached 27% The administration seems not very appropriate; and G, K of liver elimination are 0. N role of recoverability larger, and reported in the literature G, clavulanic acid, lanatosid C similar to the lower N accumulation and less toxic, both Similar to those reported in the literature; the treatment index was 6.0, similar to that reported in the literature as claudin; suggesting that N use was safer.