最近将编码病毒蛋白的DNA插入质粒载体,注入肌肉称为DNA基因疫苗。接种的DNA无需特别处理,易被摄入肌细胞的胞质内表达编码蛋白,表达蛋白被胞浆的蛋白酶分解为多肽,最后作为T细胞决定簇,与MHC Ⅰ类分子结合,提呈至细胞上,由此抗原活化免疫系统,诱导抗原特异的T杀伤淋巴细胞(CTL)。该过程与活疫苗所致的细胞免疫过程基本相同,但有下列不同:DNA基因疫苗在摄入细胞内不复制;DNA基因疫苗通过各种病毒蛋白基因的杂交接种可以产生对多种病毒的免疫。 DNA基因疫苗或许能够对流感与 Recently, DNA encoding a viral protein was inserted into a plasmid vector and injected into the muscle as a DNA gene vaccine. Inoculated DNA, which requires no special treatment, can be easily expressed in the cytoplasm of muscle cells to express the encoded protein. The expressed protein is degraded into a polypeptide by the cytoplasmic protease. Finally, it acts as a T cell determinant and binds to the MHC class I molecule and is presented to the cell , Whereby the antigen activates the immune system and induces antigen-specific T killer lymphocytes (CTLs). This process is basically the same as the cellular immunity caused by live vaccines, but with the following differences: DNA gene vaccines are not replicated in the ingested cells; DNA vaccines can produce immunity to various viruses by inoculation of various viral protein genes . DNA genetic vaccine may be able to flu and