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目的:探讨脊索瘤组织中CXCR4的表达情况,并分析其在脊索瘤侵袭和复发中的作用及临床意义。方法:应用免疫组织化学方法检测42例脊索瘤及16例骨样骨瘤患者标本中CXCR4的表达,并分析其与侵袭复发的关系。结果:脊索瘤组织中CXCR4的阳性表达率为80%(34/42),而在骨样骨瘤中的表达率为12.5%(2/16),两者比较有显著差异(P<0.01),在正常脊索组织中无表达。CXCR4的表达与脊索瘤患者的性别、年龄无关(P>0.05);而与脊索瘤有无复发有关(P<0.05)。结论:CXCR4可能在脊索瘤细胞侵袭、复发的过程中起重要作用,为进一步的研究奠定基础。
Objective: To investigate the expression of CXCR4 in chordoma and to analyze the role and clinical significance of it in invasion and recurrence of chordoma. Methods: The expressions of CXCR4 in 42 cases of chordoma and 16 cases of osteoid osteoma were detected by immunohistochemistry. The relationship between the expression of CXCR4 and invasion and recurrence was analyzed. Results: The positive rate of CXCR4 expression in chordoma was 80% (34/42), while it was 12.5% (2/16) in osteoid osteoma. There was a significant difference between the two groups (P <0.01) , No expression in normal chordal tissue. The expression of CXCR4 was not related to the gender and age of patients with chordoma (P> 0.05), but not with the recurrence of chordoma (P <0.05). Conclusion: CXCR4 may play an important role in the invasion and recurrence of chordoma cells, which lays the foundation for further research.