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获得性免疫缺陷综合征(AIDS)可能由病毒引起,本病的表现之一是辅助性T细胞与抑制性T细胞的比例倒置。AIDS常见于男性同性恋者,而后者又在供血者中占很大比例,因此,携带引起AIDS的病毒的血浆可混入血库,并被用来制备浓缩因子Ⅷ和冷沉淀。经常应用浓缩因子Ⅷ的血友病患者是否会因此罹患AIDS?许多作者研究了血友病人的辅助性T细胞与抑制性T细胞的比例。Menitove等报道14例应用浓缩因子Ⅷ的血友病人的比例为1.4,8例应用冷沉淀的血友病人为2.2,对照组为2.0。Koerper等报道13例血友病人中,有11例的比例比对照组的平均值低1个标准差以上,这13例病人中,除1例外,都经常使用浓缩因子Ⅷ。Tsoukas等报道34例使用浓缩因子Ⅷ的血友病人的比例为1.1,而对照组为1.8。有人报道51例用浓缩因子Ⅷ的血友病人的比例为1.2,而
Acquired immunodeficiency syndrome (AIDS) may be caused by a virus. One of the signs of this disease is the inverse proportion of helper T cells to suppressor T cells. AIDS is common in gay men, which in turn accounts for a large proportion of blood donors, so the blood plasma that carries the AIDS-causing virus can be mixed into blood banks and used to make concentrated Factor VIII and cryoprecipitate. Will people with hemophilia who regularly use factor VIII develop AIDS? Many authors have studied the proportion of helper T-helper and suppressor T cells in hemophilia patients. Menitove et al. Reported that the proportion of hemophiliacs in 14 patients using factor VIII was 1.4, while those in hemophilia with cryoprecipitate were 2.2 and 2.2 respectively. Koerper et al. Reported that of 13 hemophiliacs, 11 were lower than the mean of the control group by more than 1 standard deviation. Of these 13 patients, all but one of the 13 patients often used enrichment factor VIII. Tsoukas et al. Reported a ratio of 34 hemophiliacs using enrichment factor VIII to 1.1, compared with 1.8 in the control group. It was reported in 51 patients with factor VIII enrichment hemophiliacs ratio of 1.2