体外培养大鼠皮质神经元 ,用β-淀粉样蛋白 (β- AP)诱导皮质神经元凋亡。黑海参多糖使皮质神经元存活率增加 ,使神经元的 DNA电泳图谱不出现“梯子状”,使神经元的流式细胞仪分析图上不出现凋亡峰 ,表明黑海参多糖对 β- AP诱导的皮质神经元凋亡具有保护作用。 Rat cortical neurons were cultured in vitro and β-amyloid protein (β-AP) was used to induce apoptosis of cortical neurons. Black sea cucumber polysaccharides increase the survival rate of cortical neurons, so that the DNA electrophoresis pattern of neurons does not appear “ladder-like”, so that no apoptotic peak appears on the flow cytometry analysis diagram of neurons, indicating that black sea cucumber polysaccharides on β-AP Induced apoptosis of cortical neurons has a protective effect.