艰难梭菌感染(Clostridium difficile infection,CDI)是常见的医院获得性感染之一,它是由肠道致病性艰难梭菌过度增殖并释放毒素引起的以肠道为主要表现的感染性疾病,临床表现可从轻度自愈性腹泻到严重的伪膜性肠炎、脓毒综合征、中毒性巨结肠甚至肠穿孔。目前超过60%的患者在初次治疗后会出现复发,常规治疗的失败率增加、治疗后复发都给医生带来了 Clostridium difficile infection (CDI) is one of the common hospital-acquired infections. It is an infectious disease mainly caused by intestine caused by excessive proliferation of intestinal pathogenic Clostridium difficile and release of toxins. Clinical manifestations may range from mild self-healing diarrhea to severe pseudomembranous colitis, sepsis syndrome, toxic megacolon and even intestinal perforation. At present, more than 60% of patients relapse after initial treatment, the failure rate of conventional treatment increases, and the recurrence after treatment brings the doctor