[目的]探讨福州市的乙型肝炎病毒(HBV)感染模式和流行病学特征变化,为防治工作提供科学依据。[方法]对我市5区8县人群进行流行病学个案调查,同时检测乙肝血清标志物及HBV-DNA含量,用SPSS软件包统计分析。[结果]全市共调查1538人,乙肝表面抗原携带率为13.5%,其中>14岁人群乙肝表面抗原携带率为15.1%,≤14岁为6.8%。HBV-DNA阳性率为9.1%。沿海县人群的HBsAg阳性率高达17.7%。[结论]沿海县是我市乙型病毒性肝炎防治重点地区。 [Objective] To explore the change of hepatitis B virus (HBV) infection pattern and epidemiological characteristics in Fuzhou, and provide a scientific basis for prevention and treatment. [Methods] The epidemiological investigation was conducted in 8 districts and counties of 5 districts in our city. At the same time, the content of serum HBV-DNA and HBV-DNA in hepatitis B were detected and analyzed by SPSS software package. [Results] A total of 1538 people were surveyed in the city. The carrying rate of hepatitis B surface antigen was 13.5%. Among them, the carrying rate of HBsAg was> 15.1% in those aged> 14 years and 6.8% in ≤14 years. HBV-DNA positive rate was 9.1%. Coastal county population HBsAg positive rate as high as 17.7%. [Conclusion] Coastal county is the key area of ​​prevention and treatment of hepatitis B in our city.