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目的 :分析和总结Graves病 (GD)甲亢在抗甲状腺药物 (ATD)治疗后血清促甲状腺激素 (TSH )值转归 ,为指导临床治疗和预后判断提供帮助。方法 :门诊就诊的GD甲亢患者 3 79例 ,均选用ATD治疗 ,服药时间至少 3个月 ,治疗及停药随诊期间定期复查TT3 、TT4 、FT3 、FT4 和TSH ,并行相关性分析。结果 :①ATD治疗后TSH恢复正常的时间明显落后于甲状腺激素 (TH)降至正常的时间 ;②停药时TSH正常者复发例数明显低于TSH减低者 ;③ATD治疗过程中血清TSH值仅与TT3 具有负相关性。结论 :ATD治疗过程中TSH恢复正常的时间明显落后于TH降至正常的时间 ;血清TSH值与TT3 密切相关 ,同时可以作为判断ATD治疗预后的一个良好指标。
Objective: To analyze and summarize the serum thyrotropin (TSH) value of hyperthyroidism with Graves’ disease (GD) after antithyroid drug (ATD) treatment and provide guidance for clinical treatment and prognosis judgment. METHODS: A total of 3 79 GD hyperthyroidism patients were selected for outpatient treatment. All patients were treated with ATD for at least 3 months. The correlations between TT3, TT4, FT3, FT4 and TSH were analyzed regularly during treatment and discontinuation. Results: ① The TSH recovery time after ATD treatment lagged significantly from that of thyroid hormone (TH) to normal time; ② The number of recurrent TSH in patients with TSH was significantly lower than that of TSH after discontinuation of treatment; ③ The TSH value of serum TSD was only TT3 has a negative correlation. CONCLUSIONS: The duration of TSH return to normal after ATD treatment lagged significantly from the time when TH decreased to normal. The serum TSH value was closely related to TT3 and could be used as a good indicator to judge the prognosis of ATD.