垂体瘤是颅内常见良性肿瘤,占颅内肿瘤的10%-25%[1]。临床表现为对周围组织的压迫和引起内分泌系统功能紊乱,部分垂体瘤表现具有侵袭性和较高复发率。部分垂体微腺瘤表现停止生长,微小泌乳素腺瘤能够自我消除,这说明在垂体细胞中存在老化机制,抑制细胞无限增殖和恶性转化[2]。老化机制目前认为是重要的防止肿瘤入侵屏障[3]。了解垂体细胞潜在的逃避侵袭性生长和恶性转化能 Pituitary tumor is a common intracranial benign tumor, accounting for 10% -25% of intracranial tumors [1]. Clinical manifestations of oppression of the surrounding tissue and cause endocrine system disorders, some pituitary tumors showed aggressive and high recurrence rate. Some of the pituitary microadenomas showed no growth and micro-prolactinomas were able to eliminate themselves, indicating that there is an aging mechanism in pituitary cells to inhibit cell proliferation and malignant transformation [2]. Aging mechanisms are currently considered important to prevent tumor invasion barrier [3]. Understand the potential escape of pituitary cells from invasive growth and malignant transformation