论文部分内容阅读
为观察肝硬化患者外周血纤溶功能变化。分别用发色底物法、酶联免疫吸附法测定 6 8例肝硬化 ,37例正常人外周血的组织型纤溶酶原激活物活性 (t PA :A)及其抗原 (t -PA :Ag) ,纤溶酶原激活物抑制物活性 (PAI-A)及D -二聚体。结果显示 :肝硬化患者纤溶指标t -PA :A、t -PA :Ag及D -二聚体显著高于正常人 ,失代偿者明显高于代偿者。而PAI-A变化与其相反。提示 :肝硬化患者外周血存在不同程度的纤溶活性增高 ,测定上述指标对估计肝功能及临床用药有指导意义。
To observe the changes of peripheral fibrinolysis in cirrhotic patients. Tissue plasminogen activator activity (t PA: A) and its antigen (t-PA: A) in 68 cases of cirrhosis and 37 normal human peripheral blood were measured by chromogenic substrate method and enzyme-linked immunosorbent assay Ag), plasminogen activator inhibitor activity (PAI-A) and D-dimer. The results showed that the fibrinolytic indexes t-PA: A, t-PA: Ag and D-dimer in patients with cirrhosis were significantly higher than those in normal people, and those with decompensation were significantly higher than compensators. The PAI-A changes the opposite. Tip: There are varying degrees of fibrinolytic activity in patients with cirrhosis of the peripheral blood increased, the above indicators for the assessment of liver function and clinical use of drugs is instructive.