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(一)脑脊髓病所有的抗菌素均可有神经毒性作用.全身给药可因肾功衰竭或肾性无尿有发生惊厥和脑损害的危险,例如丙磺舒就是这样,这种综合征也可因鞘内注射有毒的药物而引起的,如未经稀释的青霉素和链霉素等.高血浓度的氨基糖苷(链霉素、卡那霉素和庆大霉素),利尿剂(利尿酸和呋喃苯胺酸)有耳毒性作用.不适当的抗菌疗法可引起无菌性脑膜炎.在使用细胞毒性药物或长期应用类固醇疗法的过程中可引起细菌性脑膜炎或神经系统霉菌病.包
(A) all myeloablative antibiotics can have neurotoxic effects. Systemic administration may be due to renal failure or renal anuria convulsions and brain damage risk, such as probenecid is the case, this syndrome is also May be due to intrathecal injection of toxic drugs caused, such as undiluted penicillin and streptomycin, etc. High concentrations of aminoglycosides (streptomycin, kanamycin and gentamicin), diuretics (Lee Uric acid and furosemide) ototoxicity Improper antimicrobial therapy can cause aseptic meningitis, which can cause bacterial meningitis or neuro-mycosis during the use of cytotoxic drugs or long-term steroid therapy