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胰岛β细胞选择性破坏,胰岛素分泌减少,可引起1型糖尿病。胰岛β细胞选择性破坏的机制以往认为是感染及免疫因素造成的胰岛炎所致胰岛β细胞坏死而引起,现认为是胰岛β细胞过度凋亡所致。胰岛β细胞过度凋亡与1型糖尿病的发病密切相关。一氧化氮作为一种新发现的免疫调节分子,参与细胞凋亡过程,并在胰岛β细胞凋亡中起着十分重要的作用。其具体作用机制还不十分清楚,但一氧化氮诱导胰岛β细胞凋亡,并参与1型糖尿病的发生这一事实,还是被多数学者所公认。
Selective destruction of pancreatic β-cells, reduced insulin secretion, can cause type 1 diabetes. Selective destruction of pancreatic β-cell mechanism in the past that is caused by infection and immune factors caused by pancreatitis caused by pancreatic β-cell necrosis is caused, it is thought to be caused by excessive apoptosis of pancreatic β-cells. Islet β-cell apoptosis is closely related to the pathogenesis of type 1 diabetes. Nitric oxide, as a newly discovered immunomodulatory molecule, participates in the process of apoptosis and plays a very important role in pancreatic β-cell apoptosis. Its specific mechanism of action is not yet fully understood, but the fact that nitric oxide induces islet β-cell apoptosis and is involved in the development of type 1 diabetes is still recognized by most scholars.