论文部分内容阅读
目的探讨直肠癌根治术后进行侧方淋巴结清扫对患者局部复发率、5年生存率的影响,从而为临床直肠癌根治性手术中是否应常规进行淋巴结清扫提供依据。方法利用META分析的方法综合国内外1994至2006年关于直肠癌侧方淋巴结清扫与患者预后关系的文献。结果符合要求纳入分析的文献共8篇,累计病例2669例,其中行侧方淋巴结清扫1324例。直肠癌根治术后行侧方淋巴结清扫患者与未行侧方淋巴结清扫的局部复发率比较,其合并ORs值分别为0．52 (95%CI=0．39～0．68,P＜0．01)；患者5年生存率合并ORs值分别为1．99(95%CI=1．78～2．12,P＜0．01)。结论直肠癌根治术后进行侧方淋巴结清扫可降低患者局部复发率,提高5年生存率。
Objective To investigate the effect of lateral lymph node dissection after radical resection of rectal cancer on the local recurrence rate and 5-year survival rate in patients with rectal cancer, so as to provide a basis for routine lymph node dissection in radical surgery of rectal cancer. Methods Meta-analysis was used to synthesize the literature from 1994 to 2006 on the relationship between lateral lymph node dissection and prognosis in patients with rectal cancer. Results A total of 8 articles were included in the analysis, with a total of 2669 cases, of which 1324 were lateral lymphadenectomy. The combined ORs were 0.52 (95% CI = 0.39-0.68, P <0) in patients with rectal cancer who underwent radical lymphadenectomy compared with those without lateral lymph node dissection. 01). The 5-year survival rates of patients with combined ORs were 1.99 (95% CI = 1.78-2.12, P <0.01). Conclusions Lateral lymph node dissection after radical resection of rectal cancer can reduce the local recurrence rate and improve the 5-year survival rate.