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目的研究多枝雾水葛提取物对感染诱发皮肤溃疡的治疗作用,并初步探讨其作用机制。方法建立大鼠细菌性外伤感染皮肤溃疡模型,通过测定大鼠皮肤的脓肿体积、胸腺指数、脾脏指数、血清中肿瘤坏死因子-α(TNF-α)和白细胞介素-1(IL-1),观察局部病理形态,评价多枝雾水葛提取物对大鼠皮肤溃疡的疗效。结果多枝雾水葛提取物能显著减轻外伤性溃疡大鼠的脓肿体积(P<0.05或P<0.01),改善局部病理形态,促进溃疡愈合,能明显升高脾脏指数(P<0.05),降低大鼠血清中IL-1的含量(P<0.05)。结论多枝雾水葛提取物对外伤感染引起的皮肤溃疡具有消肿排脓及促进皮肤愈合作用,其机制可能与抑制炎症因子的释放和调节免疫有关。
Objective To study the therapeutic effect of Dracaena chinensis Puerariae extracts on skin ulcers induced by infection and to explore its mechanism. Methods The model of skin ulcer caused by bacterial trauma in rats was established. The abscess volume, thymus index, spleen index, TNF-α and IL-1 in serum of the rats were determined. , Observe the local pathological morphology, evaluate the effect of Rhizoma Polygonatum Puerariae extract on rat skin ulcer. Results Fructus Sophora patera extract could significantly reduce the abscess volume (P <0.05 or P <0.01), improve the local pathology, promote the healing of ulcer, and significantly increase the spleen index (P <0.05) Reduce the serum IL-1 content (P <0.05). Conclusion Dracaenae patens extracts have the effect of swelling and purging and skin healing on skin ulcers caused by traumatic infection. The mechanism may be related to the inhibition of the release of inflammatory cytokines and the regulation of immunity.