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Ifenprodil酒石酸系2-哌啶-链醇衍生物(4-苄基-α-(对-羟基)-β-甲基-1-哌啶-乙醇-L(+)-酒石酸-水化合物),有α-肾上腺素能阻断以及周围和中枢血管扩张作用,还有轻微的拟β-肾上腺素能和抗组织胺活性。本文报告Ifenprodil对抗氰化物中毒的效果与机理。观察静脉注入氰化钠的大鼠、豚鼠、兔的呼吸、血压和心率的变化。治疗组在注射氰化钠前30分钟静脉注射Ifenprodil酒石酸(0.25×10~(-5)克分子/kg);以注射盐水的动物作为对照。对照组中动物有暂时的呼吸增加、血压上升后,呼吸、血压、心率都逐渐下降;
Ifenprodil tartaric acid 2-piperidine-alkanol derivatives (4-benzyl-α- (p -hydroxy) -β-methyl-1 -piperidine-ethanol-L α-adrenergic blockade and peripheral and central vasodilator effects, with mild pseudo-β-adrenergic and antihistamine activity. This article reports the effectiveness and mechanism of Ifenprodil against cyanide poisoning. The changes of respiration, blood pressure and heart rate were observed in rats injected with sodium cyanide, guinea pigs and rabbits. The treatment group received intravenous Ifenprodil tartaric acid (0.25 × 10 -5 mol / kg) 30 minutes before the sodium cyanide injection. Saline injected animals served as a control. The animals in the control group had a temporary increase in respiration. After the blood pressure rose, the respiration, blood pressure and heart rate gradually decreased.