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对30例符合标准的尸检唇腺和21例Sjǒgren综合征唇腺活检标本进行组织学观察,发现导管扩张、脂肪组织聚积,腺泡萎缩呈导管样退化、间质纤维化及淋巴细胞浸润为唇腺的年龄性改变。用唇腺活检诊断Sjǒgren综合征,对<60岁的患者,除淋巴细胞浸润≥1灶/4mm~2这一主要标准外,导管扩张、脂肪组织聚积及腺泡萎缩也应作为参考指标;对≥60岁的患者,则应注意唇腺的年龄性改变。免疫组化染色显示年龄性改变和Sjǒgren综合征唇腺组织局部合成免疫球蛋白(IgG、IgA、IgM)的能力不同,IgG和IgM比IgA相对增高有助于Sjǒgren综合征的诊断.
Histological observation was performed on 30 cases of sectoral labial glands and 21 cases of Sjǒgren’s syndrome of labial gland biopsy. It was found that ductal dilation, accumulation of adipose tissue, ductal degeneration of acinar atrophy, interstitial fibrosis and lymphocytic infiltration were the most common Gland age changes. Diagnosis of Sjǒgren’s syndrome with labial gland biopsy, for patients <60 years of age, in addition to the main criteria lymphocyte infiltration ≥ 1 / 4mm ~ 2, catheter expansion, adipose tissue accumulation and acinar atrophy should also be used as a reference index; ≥ 60-year-old patients, should pay attention to the age of the labial gland changes. Immunohistochemical staining showed age-related changes and Sjǒgren syndrome labial gland local synthesis of immunoglobulins (IgG, IgA, IgM) ability to different IgG and IgM relative IgA relative increase in the diagnosis of Sjǒgren syndrome.