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目的观察哮喘患者呼出气一氧化氮(FeNO)的表达水平,探讨其与肺功能指标第1秒用力呼气量占预计值百分比(FEV1/pred)、外周血嗜酸性粒细胞(EOS)计数、血清总IgE之间的相关性及临床意义。方法选取30例支气管哮喘患者作为研究组,以及30例健康人作为对照组,观察FeNO、肺功能、外周血EOS计数及总IgE。结果哮喘组FeNO水平及外周血EOS计数、血IgE水平均明显高于健康对照组(P均<0.05);哮喘组FEV1/pred值显著低于健康对照组(P<0.05);FeNO与外周血EOS计数呈正相关(r=0.328,P<0.05);与IgE呈正相关(r=0.421,P<0.05);与FEV1/pred无明显相关性。结论 FeNO水平能够反映哮喘患者气道炎症,尤其是EOS炎症;结合肺功能指标更能全面反映哮喘疾病现况及控制水平。
Objective To observe the expression level of exhaled nitric oxide (FeNO) in patients with asthma, and to explore the relationship between FEV1 / pred and FEV1 / pred, the count of pulmonary eosinophils (EOS) Serum total IgE between the correlation and clinical significance. Methods Thirty patients with bronchial asthma were selected as study group and 30 healthy individuals as control group. FeNO, pulmonary function, peripheral blood EOS count and total IgE were observed. Results The levels of FeNO, peripheral blood EOS and blood IgE in asthma group were significantly higher than those in healthy control group (all P <0.05). The FEV1 / pred in asthma group was significantly lower than that in healthy control group (P <0.05) There was a positive correlation between EOS and EOS (r = 0.328, P <0.05), and IgE (r = 0.421, P <0.05). There was no significant correlation with FEV1 / pred. Conclusion FeNO levels can reflect airway inflammation in asthmatic patients, especially EOS inflammation. Combining with pulmonary function indexes can fully reflect the status and control of asthma diseases.