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目的探讨白细胞介素10(IL-10)和转化生长因子β1(TGF-β1)在系统性红斑狼疮(SLE)发病中的作用及其意义。方法采用酶联免疫吸附试验(ELISA)对63例初发期SLE患者(A组)、40例缓解期患者(B组)及32例健康人(C组)的外周血IL-10和TGF-β1水平进行检测,同时根据系统性红斑狼疮疾病活动指数(SLEDAI)评分对A组患者进行分析。结果 A组IL-10水平明显高于B组及C组,同时B组明显高于C组,3组间比较差异具有统计学意义(P<0.05);A组TGF-β1水平明显低于B和C组,差异具有统计学意义(P<0.05),B组TGF-β1水平与C组比较,差异无统计学意义(P>0.05)。按SLEDAI评分将A组63例患者分为三亚组:轻度活动亚组、中度活动亚组和重度活动亚组,三亚组间IL-10和TGF-β1水平比较差异有统计学意义(P<0.05),A组IL-10的表达与SLEDAI评分呈正相关,而TGF-β1的表达与SLEDAI评分呈负相关。结论 IL-10与TGF-β1共同参与了SLE的发病过程。
Objective To investigate the role and significance of interleukin 10 (IL-10) and transforming growth factor-β1 (TGF-β1) in the pathogenesis of systemic lupus erythematosus (SLE). Methods The levels of IL-10 and TGF-β1 in peripheral blood of 63 SLE patients (group A), 40 remission patients (group B) and 32 healthy subjects (group C) were detected by enzyme-linked immunosorbent assay β1 levels were measured, and according to the systemic lupus erythematosus disease activity index (SLEDAI) score analysis of patients in the A group. Results The level of IL-10 in group A was significantly higher than that in group B and C, and the level in group B was significantly higher than that in group C (P <0.05). The level of TGF-β1 in group A was significantly lower than that in group B (P <0.05). There was no significant difference in TGF-β1 level between group B and group C (P> 0.05). According to the SLEDAI score, 63 patients in group A were divided into three subgroups: mild active subgroup, moderate active subgroup and severe active subgroup. There was significant difference in the levels of IL-10 and TGF- <0.05). The expression of IL-10 in group A was positively correlated with SLEDAI score, while the expression of TGF-β1 was negatively correlated with SLEDAI score. Conclusion IL-10 and TGF-β1 participate in the pathogenesis of SLE.