【摘 要】
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口蹄疫是由口蹄疫病毒(Foot-and-mouth disease virus, FMDV)感染引起偶蹄动物的一种烈性传染病,严重危害我国及世界畜牧业发展。为突破宿主免疫应答,FMDV通过自身编码的多种结构蛋白和非结构蛋白拮抗宿主天然免疫和适应性免疫应答以达到免疫逃逸的目的。FMDV结构蛋白VP1是一种具有结合宿主细胞、诱导体液免疫应答和引起细胞凋亡的多功能蛋白。宿主肿瘤进行性位点2(TPL2)是一种重要的宿主免疫调节蛋白,可以调控宿主干扰素和细胞因子的产生,在天然免疫和获得性免疫中发挥重要作用。
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口蹄疫是由口蹄疫病毒(Foot-and-mouth disease virus, FMDV)感染引起偶蹄动物的一种烈性传染病,严重危害我国及世界畜牧业发展。为突破宿主免疫应答,FMDV通过自身编码的多种结构蛋白和非结构蛋白拮抗宿主天然免疫和适应性免疫应答以达到免疫逃逸的目的。FMDV结构蛋白VP1是一种具有结合宿主细胞、诱导体液免疫应答和引起细胞凋亡的多功能蛋白。宿主肿瘤进行性位点2(TPL2)是一种重要的宿主免疫调节蛋白,可以调控宿主干扰素和细胞因子的产生,在天然免疫和获得性免疫中发挥重要作用。
其他文献
口蹄疫(Foot-and-mouth disease, FMD)是由FMD病毒(FMDV)引起的偶蹄类动物的烈性传染病,严重威胁动物产业和畜牧业的健康可持续发展。疫苗免疫仍是目前防控FMD的主要手段之一,由于FMDV血清型之间不存在交叉免疫,其单一血清型疫苗在临床实验中的保护效果有限。因此,研发针对FMD多血清型广谱性疫苗是目前新型疫苗研发急需解决的关键问题。FMD疫苗质量是决定免疫接种成败的关键因素,目前,疫苗质量评价体系尚不健全,尤其对有效抗原的精准定量尚缺乏有效手段和理论支持。
将2000~2020年CNKI期刊全文数据库中477篇物流企业营销相关文献作为研究基础,借助可视化软件的知识图谱共现功能,绘制作者共现、物流企业营销研究关键词共现等知识图谱,结合聚类结果和词频突现情况,分析物流企业营销研究领域的研究现状、归纳国内相关研究演进路径,研究热点集中于营销策略、物流企业与营销的关系、第三方物流企业、数字化背景下的创新及问题与对策分析等;研究前沿集中于关系营销、服务营销和营销策略上;作者发文具有独立性,合作关系较少。
新冠肺炎在全球持续流行,不断危害人类生命健康。目前,已有多款新冠肺炎疫苗在我国获批临床应用,但是仍然没有临床特效药物或治疗程序可用于新冠肺炎的防治。因此,迫切需要开展临床前候选药物对新冠病毒抑制作用的系统实验研究,为阻断新冠病毒感染丰富理论依据,为尽快开发安全、有效的药物和应用程序,着力于新冠肺炎的防治奠定基础。
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