既往有的报告提及实验性肾炎及肾炎患者的肾小球局部沉着有纤维蛋白,并认为它是肾炎恶化因素之一。经作者观察,在纤维蛋白沉着的肾小球局部,其纤溶低下,特别是在使用肝素前已经沉着在肾小球的纤维蛋白,即使应用肝素也不能使其溶解。故而作者通过采用肝素、尿激酶并用疗法对其进行了研究。对象:肾炎性肾病综合征(5例)、溶血性链球菌感染后急性肾炎(急进性肾功衰竭1例)及过敏紫癜性肾炎(1例)共7例。投药方法为:肝素350～450u/kg/日持续静脉点滴,并用尿激酶1.0万u/kg/日,早晚分二次在1～2小时内持续静脉点滴,连用3日为1疗程,肝素持续用2周以上(尿激酶从肝素开始使用时并用3日)。结果:治疗后数周内出现近期疗效者有2例,为急进性肾功低下者(肾炎性肾病综合征、溶血性链球菌感染后肾炎各1例),其临床症状、检查所见及肾功 Previous reports mentioned glomerular subretinal fibrosis in patients with experimental nephritis and glomerulonephritis and considered it to be one of the deteriorating factors of nephritis. The authors observed that in fibrin-localized glomerular local fibrinolytic low, especially in the use of heparin has been deposited in glomerular fibrin, even if the use of heparin can not make it dissolved. So the author through the use of heparin, urokinase and treatment of its research. Subjects: Nephritic nephrotic syndrome (n = 5), acute nephritis (acute renal failure one case) and allergic purpura nephritis (n = 7) after hemolytic streptococcus infection. Dosage: Heparin 350 ~ 450u / kg / day continuous intravenous drip, and with urokinase 10 000 u / kg / day, morning and evening points in 1 to 2 hours continuous intravenous drip, once every 3 days for a course of treatment, heparin continued For 2 weeks or more (urokinase from heparin when used in combination with 3 days). Results: Two patients with short-term curative effect within a few weeks after treatment were those with acute renal failure (nephritis nephrotic syndrome and nephritis after hemolytic streptococcal infection). The clinical symptoms, Work