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我院自1983年9月～1991年5月对14例(16例次)膀胱颈部肿瘤患者采用保留膀胱+卡介苗(BCG)治疗,取得了较好效果。1.临床资料男12例(14例次),女2例。年龄32岁～76岁,平均57.6岁。肿瘤部位:颈部16例次,底部1例次,侧壁6例次。肿瘤数目1个～4个,最大肿瘤 5.0 ×5.0 ×6.0cm。病理(4级法):0级2例,Ⅰ级3例次,Ⅰ～Ⅱ级5例次,Ⅱ级4例次,Ⅱ～Ⅲ级2例。临床分期:Ta_2例,T_1 10例次,T_2 3例次,T_3 1例。治疗方法:除2例单纯用BCG膀胱内灌注治疗外,其余行TURBT或保守性手术+BCG治疗。2 方法和结果 BCG为巴斯德菌株(上海生物制品研究所制剂),75mg/ml,相当活菌数 3×10~8,膀胱内灌注150mg加 0.9％生理盐水60ml,1/周×6(单程疗法),接着 1/2周×6,1/月×24(维持疗法)。口服每周3次,根据OT皮试(+)、(±)、(-)分别给予225mg、412mg和825mg。术后2年每3～6月复查
In our hospital from September 1983 to May 1991 in 14 cases (16 cases) bladder neck cancer patients with retained bladder BCG treatment, and achieved good results. Clinical data of 12 males (14 cases), 2 females. Age 32 years old to 76 years old, average 57.6 years old. Tumor site: 16 cases of neck, the bottom of a case, 6 cases of lateral wall. Number of tumors 1 to 4, the largest tumor 5.0 × 5.0 × 6.0cm. Pathology (grade 4): 0 in 2 cases, Ⅰ in 3 cases, Ⅰ ~ Ⅱ in 5 cases, Ⅱ in 4 cases, Ⅱ ~ Ⅲ in 2 cases. Clinical stage: Ta_2 cases, T_1 10 cases, T_2 3 cases, T_3 cases. Treatment: In addition to two cases of simple treatment with BCG intravesical instillation, the remaining TURBT or conservative surgery + BCG treatment. 2 Methods and Results BCG Pasteur strain (Shanghai Institute of Biological Products), 75mg / ml, the viable count of 3 × 10 ~ 8, intravesical instillation of 150mg plus 0.9% saline 60ml, 1 / week × 6 One-way therapy), followed by 1/2 week × 6,1 / month × 24 (maintenance therapy). Oral 3 times a week, according to OT skin test (+), (±), (-) were given 225mg, 412mg and 825mg. 2 years after surgery every 3 to 6 months review