This article reveals the inherent evolution adjusting mechanism of regional architecture by means of considering the concept and method of "regional gene" as the research approach of regional architecture construction system, and in the meanwhile establishes the "gene database" of regional architecture and optimum technology, on the basis of the principle of sustainable development and scientific evaluation system. In addition, this article chooses the planning of model villages of cave dwellings in Loess Plateau and the construction of ecological cave dwellings for case study to prove the feasibility of the research approach.