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目的:探讨不同用量的氯解磷定治疗急性有机磷农药中毒的临床疗效。方法:选取我院收治的60例急性有机磷农药中毒患者作为研究对象,随机分为A、B两组(每组30例),均应用氯解磷定进行治疗,A组予以持续静脉注射氯,B组静脉滴注,每日3次,对比2组患者的治疗效果。结果:A组的氯解磷定用量明显比B组更多,阿托品用量明显比B组更少,P<0.05;A组的治愈率、总有效率均显著高于B组,P<0.05;A组的不良反应发生率、中间综合征发生率均显著低于B组,P<0.05。结论:与静脉滴注给药相比,持续静脉注射氯解磷定治疗有机磷农药中毒的疗效更显著,中间综合症及不良反应发生率更低,是较为安全、有效的治疗方法,值得推广应用。
Objective: To investigate the clinical effects of different dosages of chlorpheniramine for acute organophosphorus pesticide poisoning. Methods: Sixty patients with acute organophosphorus pesticide poisoning admitted to our hospital were selected as study subjects and randomly divided into A and B groups (30 in each group). All patients were treated with chlorophenanthroline. Group A was given continuous intravenous injection of chlorine , B group intravenous drip, 3 times a day, compared with the treatment effect of two groups of patients. Results: The dosage of chlorinated phosphorus in group A was more than that in group B, and the dosage of atropine was less than that in group B, P <0.05. The cure rate and total effective rate in group A were significantly higher than those in group B (P <0.05) A group of adverse reactions, the incidence of intermediate syndrome were significantly lower than the B group, P <0.05. Conclusion: Compared with intravenous drip, continuous intravenous injection of chlorpheniramine for the treatment of organophosphate pesticide poisoning is more effective, and the incidence of intermediate syndrome and adverse reactions is lower, which is a safe and effective treatment and is worth promoting application.