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Roboz等报道1例妊娠20周孕妇静注阿霉素30mg/m~24、16小时后,于羊水内未检出药物,提示本药“不通过胎盘”。作者报道1例22岁孕妇,体重64kg,体表面积1.65m~2,于妊娠17周因患何杰金氏病用ABVD(阿霉素40mgiv、博莱霉素15mgiv、长春花硷9mg-iv、氮烯咪胺600mgiv)方案治疗,引起了流产。经检验发现,阿霉素静注后15小时,羊水(<1.66ng/ml),胎脑、肠、及腓肠肌(<10 ng/g)均未检出药物;但胎肝、肾、肺组织中含阿霉素浓度>10ng/g,且胎肝内药物浓度约为当时母体血浆浓度的10倍,表明药物确已进入胎儿体内。
Roboz et al reported 1 case of pregnant women 20 weeks of pregnancy intravenous doxorubicin 30mg / m ~ 24,16 hours after the drug was not detected in the amniotic fluid, suggesting that the drug “does not pass the placenta.” The authors reported a 22-year-old pregnant woman with a body weight of 64 kg and a body surface area of 1.65 m ~ 2. He was diagnosed with Hodgkin’s disease by ABVD (doxorubicin 40 mgiv, bleomycin 15 mgiv, vinblastine 9 mg-iv, Dacarbazine 600mgiv) regimen, resulting in abortion. The test found that 15 hours after intravenous injection of adriamycin, amniotic fluid (<1.66ng / ml), fetal brain, intestine, and gastrocnemius (<10 ng / g) did not detect any drug; but fetal liver, kidney and lung tissue Containing doxorubicin concentration> 10ng / g, and fetal liver drug concentration was about 10 times the plasma concentration at that time, indicating that the drug did enter the fetus.