论文部分内容阅读
目的：观察窒息对新生儿血清肿瘤坏死因子－α（ＴＮＦ－α）值的影响。方法：用放射免疫法测定５５例窒息新生儿血清ＴＮＦ－α的变化，同时测定１５例正常足月新生儿脐动脉血作对照。结果：窒息新生儿组血清ＴＮＦ－α明显高于对照组，并且血清ＴＮＦ－α水平与Ａｐｇａｒ评分密切相关，重度窒息组比轻度窒息组血清ＴＮＦ－α明显增高。结论：ＴＮＦ－α在新生儿窒息的发病机制中起一定作用。对重度窒息患儿及早使用抗ＴＮＦ－α单克隆抗体，可减轻脑水肿，阻断继发性脑损伤。
Objective: To observe the effect of asphyxia on serum tumor necrosis factor-α (TNF-α) in neonates. Methods: The changes of serum TNF-α in 55 neonates with asphyxia were determined by radioimmunoassay. At the same time, the umbilical artery blood of 15 normal term newborns was used as control. Results: Serum levels of TNF-α in neonatal asphyxia group were significantly higher than those in control group, and serum TNF-α level was closely related to Apgar score. Serum TNF-α in severe asphyxia group was significantly higher than that in mild asphyxia group. Conclusion: TNF-α plays a role in the pathogenesis of neonatal asphyxia. Early use of anti-TNF-α monoclonal antibody in children with severe asphyxia can reduce brain edema and block secondary brain injury.