论文部分内容阅读
采用大剂量氨甲喋呤（ＨＤ＿ＭＴＸ３０００ｍｇ·ｍ－２／次）治疗２９例小儿急性淋巴细胞白血病（ＡＬＬ）８５例次。治疗前及治疗期间给予大量补液及碱化尿液；治疗开始后６ｈ和３６ｈ分别给于四氢叶酸钙（ＣＦ）口腔滴入和静脉注射。结果发生粘膜损伤４例（４７％），显著低于单纯ＣＦ静注组（Ｐ＜００５）。治疗前后肌酐、尿素氮及外周血白细胞无明显变化。提示大量补液、碱化尿液可预防ＭＴＸ的肾毒性，并能显著降低粘膜损伤的发生率。
A total of 85 pediatric acute lymphoblastic leukemia (ALL) cases were treated with high dose methotrexate (HD_MTX3000mg · m-2 / time). A large amount of rehydration and alkalinization of urine were given before treatment and during treatment; respectively, 6 h and 36 h after the start of treatment were given intramuscularly and intravenously with calciumtetrahydrofolate (CF). Results mucosal injury in 4 cases (47%), significantly lower than the simple CF group (P <0 05). Before and after treatment, creatinine, urea nitrogen and peripheral white blood cells showed no significant changes. Tip a lot of rehydration, alkaline urine can prevent renal toxicity of MTX, and can significantly reduce the incidence of mucosal injury.