论文部分内容阅读
目的观察左归丸对左旋单钠谷氨酸（ｍｏｎｏｓｏｄｉｕｍｇｌｕｔａｍａｔｅＭＳＧ）大鼠下丘脑－垂体－肾上腺轴的影响，探讨肾阴虚与ＭＳＧ大鼠下丘脑－垂体－肾上腺轴亢进的联系。方法新生期大鼠出生后的第２、４、６、８、１０天皮下注射ＭＳＧ（４ｍｇ／ｇ／ｄ），成年后以不同浓度的左归丸灌胃１个月，观察血中ＣＯＲＴ，ＡＣＴＨ及下丘脑ＣＲＨ含量的变化。结果ＭＳＧ大鼠血ＣＯＲＴ、ＡＣＴＨ和下丘脑ＣＲＨ含量明显升高（Ｐ＜０．０５），不同浓度的左归丸灌胃后，能不同程度地减轻ＨＰＡ轴的功能亢进状态。提示ＭＳＧ大鼠所表现的ＨＰＡ轴功能亢进与肾阴虚有关，左归丸能有效地改善ＨＰＡ轴的功能亢进
Objective To observe the effect of Zuogui Pill on the hypothalamus-pituitary-adrenal axis in rats with monosodium glutamate (MSG) and to explore the relationship between kidney deficiency and hypothalamus-pituitary-adrenal axis in MSG rats. Methods MSG (4mg/g/d) was injected subcutaneously on the second, fourth, sixth, eighth and tenth day after birth in neonatal rats. After adulthood, Zuogui Pill with different concentrations was given for one month to observe the CORT in blood. Changes in ACTH and CRH content in the hypothalamus. Results The levels of CORT, ACTH and CRH in the hypothalamus of MSG rats were significantly increased (P<0.05). Different concentrations of Zuogui Pills can relieve the hyperfunction of HPA axis to varying degrees. It is suggested that the hyperactivity of HPA axis in MSG rats is related to kidney yin deficiency. Zuogui pill can effectively improve the function of HPA axis.