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本文报道了L-苏氨酸同Cu(II),Zn(II),Fe(II),Mn(II),Ca(II),Mg(II),Ni(II),Cd(II)的二元及三元配合物的pH电位法研究.电位滴定数据是使用MINIQUAD和ESTA计算机程序处理的.在每个体系中确定了最佳配合物粒子模型,并测定了在生理条件下(温度为37±0.1,℃离子强度为150mmol·dm~(-3)NaCl)的稳定常数.结果表明在铜配合物中Cu·Thr·His混配配合物是与Cu(His)_2~-同样重要的配合物,因此需要重新计算在血浆中铜在这些配合物中的分布.虽然苏氨酸可以看作为三齿配位体,但本工作的结果并无证据支持羟基参与配位.然而在Cd-Thr-His体系中,Cd·Thr·His同它的1:2母体二元配合物相比表现了显著的稳定性,这可能显示了不同的配位状况.但这一点有待于进一步证实.
In this paper, the effects of L-threonine on the reduction of L-threonine in the presence of Cu (II), Zn (II), Fe (II), Mn (II), Ca (II), Mg The investigation of the pH and potential of the ternary and ternary complexes was carried out.Potentiometric data were processed using the MINIQUAD and ESTA computer programs.The optimum complex particle model was determined in each system and was determined under physiological conditions ± 0.1, and ionic strength of 150 mmol · dm -3 NaCl) .The results show that Cu · Thr · His complex is the same important coordination with Cu (His) _2 ~ in copper complex Therefore, it is necessary to recalculate the distribution of copper in these complexes in plasma.Although threonine can be considered as a tridentate ligand, the results of this work do not support the participation of hydroxyl groups in the coordination.However, in the Cd-Thr -His system, Cd · Thr · His showed significant stability compared with its 1: 2 parent binary complex, which may show different coordination status, but this needs to be further confirmed.