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1胰岛素增敏剂胰岛素增敏剂是指能提高机体胰岛素敏感性,改善胰岛素抵抗状态的药物,包括化学结构、作用机理各不相同的多种药物。目前在临床上常用的有双胍类、α-糖苷酶抑制剂、某些降压药及调脂药;开始使用或即将应用的有噻唑烷二酮类药物、胰岛素降解抑制剂、胰升糖素样肽-1等。1.1双胍类其主要品种有二甲双胍、苯乙双胍及丁双胍。二甲双胍较少引起乳酸性酸中毒,使用最为广泛。该药并不直接刺激
1 insulin sensitizers Insulin sensitizers are able to improve the body’s insulin sensitivity, improve insulin resistance of the state of the drug, including the chemical structure, mechanism of action of different drugs. Currently used in clinical clinics are biguanides, α-glucosidase inhibitors, some antihypertensive agents and lipid-lowering drugs; started or is about to be used thiazolidinedione drugs, inhibitors of insulin degradation, glucagon Like peptide-1 and so on. 1.1 Biguanide The main varieties of metformin, phenformin and buformin. Metformin causes less lactic acidosis, the most widely used. This medicine is not directly stimulated