目的　筛选一种合适的剂型以降低鼻用制剂的鼻纤毛毒性。方法　以盐酸普萘洛尔为模型药物，分别制备微球剂、复合乳剂和环糊精包合物。以在体蟾蜍上腭粘膜纤毛为动物模型，评价上述鼻用制剂对盐酸普萘洛尔纤毛毒性的改善作用。结果　微球剂能有效地降低盐酸普萘洛尔的纤毛... Objective To screen a suitable dosage form to reduce nasal cilia toxicity in nasal preparations. Methods Propranolol hydrochloride was used as a model drug to prepare microsphere, composite emulsion and cyclodextrin inclusion compound respectively. In vivo toad palate mucosal cilia animal model, to evaluate the above nasal preparations of propranolol hydrochloride cork to improve the role of toxicity. Results Microspheres can effectively reduce propranolol hydrochloride cilia ...