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目的:探讨补肾活血方-丹寿汤对抗磷脂抗体致妊娠丢失的影响。方法:将100只10周受孕SD大鼠随机分为2组,每组又分补肾活血组(A)、补肾组(B)、活血组(C)、模型组(D)和空白孕鼠组(E),自孕1d起,A、B、C组分别予丹寿汤、补肾方、活血方灌胃,D、E组予生理盐水灌胃作对照,其间A、B、C、D组于孕8d、孕12d多部位皮下注射15mg/ml纯化后ACA蛋白液或LA蛋白液,E组皮下注射相应生理盐水,直至孕第15d处死取材。结果:与模型组相比,A、B、C组的胚胎吸收率、ACA、APTT水平均降低(P<0.01),胎盘病理现象有明显改善,A与C组的胚胎重量有明显增加(P<0.01,P<0.05),但均以补肾活血组效果显著(P<0.05)。结论:补肾活血方能明显降低APA水平,抵制胚胎吸收,增加胚胎重量,提高妊娠成功率。
Objective: To investigate the effect of Bushen Huoxue Recipe Danshutang on the loss of pregnancy induced by antiphospholipid antibody. Methods: A total of 100 10-week pregnant SD rats were randomly divided into two groups. Each group was divided into two groups: Bushen Huoxue group (A), Bushen group (B), Huoxue group (C), model group (D) (E). From the 1st day of pregnancy, the rats in groups A, B and C were given Danshou decoction, Bushen recipe and Huoxue decoction separately. On the 8th day of pregnancy and the 12th day of pregnancy, 15 mg / ml purified ACA protein solution or LA protein solution was subcutaneously injected into multiple sites on the 12th day of gestation. E group rats were injected subcutaneously with normal saline until the 15th day of pregnancy. Results: Compared with the model group, the embryo absorptivity, ACA and APTT levels in groups A, B and C were decreased (P <0.01), and the pathological changes of placenta were significantly improved. The embryo weights in groups A and C were significantly increased (P <0.01, P <0.05), but all of them were significantly better than those of Bushenhuoxue group (P <0.05). Conclusion: Bushen Huoxue can obviously reduce the level of APA, resist the embryo absorption, increase the embryo weight, and improve the success rate of pregnancy.