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目的：观察自制一级微铜圈栓塞兔肾动脉的病理改变，为临床提供实验依据。方法用直径0．1～0．23mm导电用铜丝（纯度99．9％）制成直径0．48～0．74mm的一级微铜圈，经3F微导管释放栓塞兔肾动脉末梢支，于栓塞术后不同时间观察血管闭塞情况和病理学改变。结果栓塞术后3天、1周、2周、4周、6周和12周，动脉造影血管管腔闭塞时可见到血栓的形成。结论自制一级微铜圈诱发血栓形成，血栓机化，血管壁炎性病变，管腔闭塞，栓塞组织缺血性梗死，栓塞血管少量可再通。“,”Objective The purpose of this study was to evaluate the histopathologic manifestation o f the dog renal atery embolized with self‐made first level copper coils ,and to provide the experimental evidence fo rclinic .Methods First level of pure copper micro‐coil (Φ :0 .48~0 .74 mm) made from 0 .1~0 .23 mm diameter pure copper wire .Renal artery embo‐lization with first level pure copper coil was performed through 3F catheter in rabbits .After the embolization ,the arteriog‐raphy and the tissue histology were respectively evaluated at different time intervals .Results After the embolization for 3 days ,1w,2w,4w,6wand 12w,arteriography vascular lumen thrombosis can be seen when the occlusion was formed . Conclusion Self‐made first level copper coils induced thrombosis and a severe form panarteritis .Organization of the thrombos then take place and a complete occlusion of the vessels occurs ,leading to severe ischemia as infarction of emboli‐zed area .