肾素(R)—血管紧张索(AT)系统[RAS]和激肽释放酶(NN)—激肽(N)系统[NNS]都调节肾循环和细胞外液量。R和NN这二个酶均形成并储存在肾内。N和AT对肾循环有拮抗作用,但共同促进PG合成,它们的释放又受PG控制,三者相互作用。肾皮质外层中R和NN浓度最高,向髓质逐渐减少。RAS主要作用于血管而NNS主要作用于肾小管,不排除AT对盐、水重吸收及N对肾血流的调节作用。肾静脉血中R与PG浓度、尿中NN与PG浓度均呈正相关。盐皮质素可促进NN分泌, Both renin (R) - angiotensin (AT) system [RAS] and kallikrein (NN) - kinin (N) systems [NNS] regulate renal circulation and extracellular fluid volume. Both R and NN enzymes are formed and stored in the kidney. N and AT have antagonistic effects on renal circulation, but together to promote PG synthesis, their release is controlled by PG, the three interactions. R and NN concentrations in renal cortical outermost layer, gradually reduced to the medulla. RAS mainly acts on the blood vessels and NNS mainly acts on the renal tubules, does not rule out AT AT salt, water reabsorption and N on renal blood flow regulation. Renal venous blood R and PG concentrations, urinary NN and PG concentrations were positively correlated. Mineralocorticoid can promote NN secretion,