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目的探讨高海拔地区饮茶型氟中毒的发病机制。方法动态观察高海拔地区饮茶型氟中毒大鼠血清碱性磷酸酶(ALP)活性、钙(Ca)、磷(P)水平。结果砖茶水组ALP活性呈逐渐下降趋势,但仍高于对照组;砖茶水组血清Ca在30d时低于对照组,以后逐渐回升接近对照组水平;砖茶水组血清P在30d时高于对照组,以后逐渐下降接近对照组水平。结论高海拔饮茶型氟中毒可能存在较为复杂的发病机制。
Objective To investigate the pathogenesis of drinking-type fluorosis in high altitude areas. Methods The serum alkaline phosphatase (ALP) activity, calcium (Ca) and phosphorus (P) levels in rats with fluorosis of drinking tea in high altitude area were dynamically observed. Results The ALP activity in brick tea water group decreased gradually, but was still higher than that in control group. Serum Ca in brick tea water group was lower than that in control group on 30th day, then gradually rose to the level of control group. Serum P in brick tea water group was higher than control at 30th day Group, then gradually decreased close to the control group level. Conclusion High-altitude drinking-type fluorosis may have a more complicated pathogenesis.