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应用~(125)Ⅰ标记 VitB_(12)(下称 VB_(12))放免测定法观察豚鼠静注甘油后血清和内耳外淋巴液中外源性 VB_(12)浓度的变化。结果表明,血迷路屏障对于外源性 VB_(12)由血液向外淋巴系统的转运具有明显的时间延搁和浓度限定。静注甘油可以促进 VB_(12)向外淋巴系统的转运过程。提示甘油对于血迷路屏障具有可逆性开放作用。
The concentration of exogenous VB 12 in serum and inner ear lymphatic fluid of guinea pigs after intravenous injection of glycerol was measured by radiolabeling (~ (125) Ⅰ) labeled with VitB 12 (VB 12). The results show that the blood leaking barrier has a significant time delay and concentration restriction on the exogenous VB 12 translocation from the blood to the lymphatic system. Intravenous glycerol can promote VB_ (12) to the lymphatic system of the transport process. Suggesting that glycerol has a reversible and open effect on the blood leaking barrier.