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目的:探讨抗精神病药物对精神分裂症患者血糖的影响。方法选取2012年1月—2014年6月重庆市江北区精神卫生中心收治的精神分裂症患者126例,随机分为A组、B组、C组,各42例。A组患者予以氯丙嗪治疗,B组患者予以阿立哌唑治疗,C组患者予以喹硫平治疗。观察3组患者治疗前(入院时)、治疗第4周、第8周、第12周血糖水平及治疗第12周高血糖发生情况。结果治疗前、治疗第4周、第8周、第12周3组患者血糖水平比较,差异无统计学意义( P>0.05), A组患者治疗后第12周血糖水平高于治疗前,差异有统计学意义( P0. 05);the twelfth weeks after treatment blood glcose level of A group higher than before treatment(P<0. 05);the for twelfth weeks after treatment,hyperglycemia incidence of B group and C group was lower than that of A group(P0. 05). Conclusion Chlorpromazine has great effect on blood glucose in patients with schizophrenia,aripiprazole and quetiapine has less influence on blood glucose in patients with schizophrenia.