论文部分内容阅读
目的:研究慢性阻塞性肺病(COPD)患者急性加重期外周血白细胞介素-8(IL-8)、肿瘤坏死因子-a(TNF-a)及胰岛素样生长因子-I(IGF-I)表达变化的临床意义。方法:选取2013年12月-2014年12月我院收治的COPD急性加重患者100例为观察组,选取同期健康体检者100例为对照组,检测观察组患者治疗前、治疗稳定后及对照组外周血IL-8、TNF-α及IGF-I水平。结果:观察组患者治疗前外周血IL-8、TNF-α及IGF-I水平显著高于治疗稳定后,差异有统计学意义(P<0.05);观察组患者治疗稳定后外周血IL-8、TNF-α及IGF-I水平显著高于对照组,差异有统计学意义(P<0.05)。结论:COPD急性加重期外周血IL-8、TNF-α及IGF-I水平显著增高,治疗稳定后其水平显著降低,IL-8、TNF-α及IGF-I水平对COPD的诊断和治疗具有重要意义。
Objective: To investigate the expression of interleukin-8 (IL-8), tumor necrosis factor-a (TNF-a) and insulin-like growth factor-I (IGF-I) in patients with chronic obstructive pulmonary disease (COPD) The clinical significance of change. Methods: 100 cases of acute exacerbation of COPD admitted from December 2013 to December 2014 in our hospital were selected as the observation group, and 100 healthy subjects were selected as the control group in the same period. The patients in the observation group were treated before treatment, after the treatment was stable and in the control group Peripheral blood IL-8, TNF-α and IGF-I levels. Results: Before treatment, the levels of IL-8, TNF-α and IGF-I in peripheral blood of patients in observation group were significantly higher than those of the control group after treatment, the difference was statistically significant (P <0.05) , TNF-α and IGF-I levels were significantly higher than the control group, the difference was statistically significant (P <0.05). CONCLUSIONS: The levels of IL-8, TNF-α and IGF-I in peripheral blood of COPD patients increased significantly after acute exacerbation of COPD and the levels of IL-8, TNF-α and IGF-I were significantly decreased after stable treatment. Significance.