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目的研究复发性中高度非霍奇金淋巴瘤(NHL)的解救治疗。方法 26例患者均采用DICE方案化疗,异环磷酰胺(IFO)1.0g/m~2静滴,第1～4天;美司钠(Mesna)用量为IFO的60%于IFO 0、4、8h静脉冲入;地塞米松(Dexamethasone)10mg静滴,第1～4天;顺铂(DDP)2 5mg/m~2静滴,第1～4天;足叶乙甙(Vp-16)10 0mg/m~2静滴,第1～4天。4周为1疗程,连用2疗程评价疗效。结果 CR2 3.1%(6/26),PR4 6.1%(12/26),RR 6 9.2%(18/26),毒副反应主要是骨髓抑制、恶心、呕吐、脱发等。给予对症处理后均能缓解,无治疗相关病死率。结论DICE方案可作为复发性中高度NHL的解救治疗。
Objective To study the rescue and treatment of recurrent high-grade non-Hodgkin’s lymphoma (NHL). Methods Twenty-six patients were treated with DICE regimen. Ifosfamide (IFO) 1.0g / m ~ 2 was intravenously administered for 1 to 4 days. The dosage of Mesna was 60% of IFO at IFO 0,4, 8h intravenous infusion; dexamethasone 10mg intravenous infusion, the first 4 days; cisplatin (DDP) 25mg / m 2 intravenous infusion, the first 4 days; etoposide (Vp-16) 10 0mg / m ~ 2 intravenous infusion, the first 4 days. 4 weeks for a course of treatment, once every 2 courses of evaluation efficacy. Results CR2 3.1% (6/26), PR4 6.1% (12/26), RR 6 9.2% (18/26). The adverse reactions were mainly myelosuppression, nausea, vomiting and hair loss. Give symptomatic treatment can be alleviated, no treatment-related mortality. Conclusion DICE regimen can be used as a rescue treatment for recurrent high-grade NHL.