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目的 :探讨兔右冠脉缺血预适应 (IP)与缺血再灌注损伤 (IR)的相关性.方法 :以单纯缺血 6 0 min+再灌注 6 0 min(IR)为对照 ,观察经 IP(缺血 5min+再灌注 10 min)后 IR心肌缺血型 S- T段、超微结构改变及再灌注心律失常发生率.结果 :较之 IR组 ,IP组的 ST段明显下移 ,电镜下见右室和右房心肌超微结构改变明显减轻 ,缓慢型再灌注心律失常的发生率明显减少.结论 :清醒兔右冠脉 IP可减少 IR引起的右心缺血性超微结构损伤及再灌注心律失常发生率“,”Objective:To explore association between ischemia|preconditioning(IP) of right coronary artery and ischemia|reperfusion(IR) injury in conscious rabbits.Methods:Compared with the IR group(ischemia 60min+reperfusion 60min),the changes of ischemia S|T segment,ultrastructural injury and accidence of reperfusion arryhthmia in IP group[(IR after PC(ischemia 15 min+reperfusion 10 min)] had been studied.Results:IP markedly reduce elevated of ST segment,ultrastructural injury and accidence of reperfusion bradycardia arrhythmias by IR than that of IR group.Conclusion:The results suggest that IP of right coronary artery may reduce the ischemic ultrastructural injury of right myocardium and reperfusion arrhythmia by IR in the concious rabbits. Author′s address Dept of Cardiology,Affiliated Union Hospital of Fujian University,Fuzhou,350001