Using the 28°C isotherm to define the Western Pacific Warm Pool(WPWP), this study analyzes the seasonal variability of the WPWP thermohaline structure on the basis of the monthly-averaged sea temperature and salinity data from 1950 to 2011, and the dynamic and thermodynamic mechanisms based on the monthly-averaged wind,precipitation, net heat fluxes and current velocity data. A DT=–0.4°C is more suitable than other temperature criterion for determining the mixed layer(ML) and barrier layer(BL) over the WPWP using monthly-averaged temperature and salinity data. The WPWP has a particular thermohaline structure and can be vertically divided into three layers, i.e., the ML, BL, and deep layer(DL). The BL thickness(BLT) is the thickest, while the ML thickness(MLT) is the thinnest. The MLT has a similar seasonal variation to the DL thickness(DLT) and BLT.They are all thicker in spring and fall but thinner in summer. The temperatures of the ML and BL are both higher in spring and autumn but lower in winter and summer with an annual amplitude of 0.15°C, while the temperature of the DL is higher in May and lower in August. The averaged salinities at these three layers are all higher in March but lower in September, with annual ranges of 0.41–0.45. Zonal currents, i.e., the South Equatorial Current(SEC)and North Equatorial Counter Current(NECC), and winds may be the main dynamic factors driving the seasonal variability in the WPWP thermohaline structure, while precipitation and net heat fluxes are both important thermodynamic factors. Higher(lower) winds cause both the MLT and BLT to thicken(thin), a stronger(weaker)NECC induces MLT, BLT, and DLT to thin(thicken), and a stronger(weaker) SEC causes both the MLT and BLT to thicken(thin) and the DLT to thin(thicken). An increase(decrease) in the net heat fluxes causes the MLT and BLT to thicken(thin) but the DLT to thin(thicken), while a stronger(weaker) precipitation favors thinner(thicker)MLT but thicker(thinner) BLT and DLT. In addition, a stronger(weaker) NECC and SEC cause the temperature of the three layers to decrease(increase), while the seasonal variability in salinity at the ML, BL, and DL might be controlled by the subtropical cell(STC). Using the 28 ° C isotherm to define the Western Pacific Warm Pool (WPWP), this study analyzes analyzes the seasonal variability of the WPWP thermohaline structure on the basis of the monthly-averaged sea temperature and salinity data from 1950 to 2011, and the dynamic and thermodynamic mechanisms based on the monthly-averaged wind, precipitation, net heat fluxes and current velocity data. A DT = -0.4 ° C is more suitable than other temperature criterion for determining the mixed layer (ML) and barrier layer (BL) over the The WPWP has a particular thermohaline structure and can be vertically divided into three layers, ie, the ML, BL, and deep layer (DL). The BL thickness (BLT) is the thickest, The MLT has a similar seasonal variation to the DL thickness (DLT) and BLT. They are all thicker in spring and fall but thinner in summer. The temperatures of the ML and BL are both higher in spring and autumn b ut lower in winter and summer with an annual amplitude of 0.15 ° C while the temperature of the DL is higher in May and lower in August. The averaged salinities at these three layers are all higher in March but lower in September, with the annual ranges of 0.41-0.45. Zonal currents, ie, the South Equatorial Current (SEC) and North Equatorial Counter Current (NECC), and winds may be the main dynamic factors driving the seasonal variability in the WPWP thermohaline structure, while precipitation and net heat fluxes Higher (lower) winds cause both the MLT and BLT to thicken (thin), stronger (weaker) NECC induces MLT, BLT, and DLT to thin (thicken), and a stronger both of MLT and BLT to thicken (thin) and the DLT to thin (thicken). An increase (decrease) in the net heat fluxes causes the MLT and BLT to thicken (thin) but the DLT to thin stronger (weaker) precipitation favors thinner (thicker) MLT but thicker (thinner) BLT an d DLT.In addition, a stronger (weaker) NECC and SEC cause the temperature of the three layers to decrease (increase), while the seasonal variability in salinity at the ML, BL, and DL might be controlled by the subtropical cell (STC).